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Yichen graduated from Peking University, China with a BSc in Biological Science and Applied Mathematics. She then pursued a doctorate in Computational Biology at the University of Cambridge (funded by Wellcome Trust), and meanwhile, a part-time online Master's in Computer Science with Georgia Institute of Technology. Her PhD explored mutational processes in normal human tissues under the supervision of Professor Sir Mike Stratton and Dr Peter Campbell. She is now a Postdoctoral Fellow in the Cancer, Ageing and Somatic Mutation Programme at the Wellcome Sanger Institute.